Description
Human Recombinant Cyclophilin B is available at Gentaur for Next week delivery.
An immunophilin family protein catalyzing the isomerization of peptide bonds
Biomolecule/Target:
Alternates names: PPIB, Peptidyl prolyl isomerase B, CYPB; SCYLP; CYP-S1
Synonyms: Human Recombinant Cyclophilin B
Background Information: Cyclophilin B is a cyclosporine-binding protein. It is both secreted and retained in the ER. When secreted, Cyclophilin B mediates chemotaxis and T cell adhesion to fibronectin. This is likely due to its prolyl cis/trans isomerase activity. Intracellularly, Cyclophilin B appears to serve as a molecular chaperone for molecules destined for secretion. It does so via stabilization, and facilitating the activity of additional chaperones. It also bind to cells derived from T- and B-lymphocytes, and may regulate cyclosporine A-mediated immunosuppression.
Reconstitution Instructions: N/A
NCBI Gene Symbol: PPIB
Gene ID: 5479
NCBI Accession: P23284
Additional Information
Size: |
100 μg |
Country of Manufacturing Origin: |
USA |
Country of Animal Origin: |
USA |
Gene Source: |
Human |
Recombinant: |
Yes |
Source: |
E. coli |
Purity by SDS-PAGE: |
≥95% |
Assay: |
SDS-PAGE |
Purity: |
N/A |
Assay 2: |
N/A |
Endotoxin Level: |
< 1.0 EU per 1 μg of protein (determined by LAL method) |
Activity (Specifications/test method): |
N/A |
Biological activity: |
Specific activity is > 220 nmoles/min/mg |
Molecular Weight: |
21.2 kDa |
Storage Temperature: |
-20°C |
Shelf Life: |
12 months |
Concentration: |
1 mg/ml |
Appearance: |
Liquid |
Handling: |
Centrifuge the vial prior to opening. |