Human CellExp™ VEGF 165, Human Recombinant

Human CellExp™ VEGF 165, Human Recombinant is available at Gentaur for Next week delivery.

A signaling protein involved in both vasculogenesis and angiogenesis

Biomolecule/Target:

Alternates names: Vascular endothelial growth factor A, VEGF-A, Vascular permeability factor, VPF, Folliculostellate cell-derived growth factor, Glioma-derived endothelial cell mitogen, VEGF, MGC70609.

Synonyms: Vascular endothelial growth factor A, MVCD1, VEGF, VEGF165, VPF, MGC70609, Vascular Endothelial Growth Factor A precursor, Vascular Permeability Factor, VEGFA

Background Information: Vascular Endothelial Growth Factor (VEGF) plays a key role in tumor angiogenesis in many cancers. The VEGF family consists of seven secretory glycoproteins: VEGF-A, VEGF-B, VEGF-C, VEGF-D, VEGF-E, VEGF-F and Placental Growth Factor (PlGF). The binding of VEGF and its receptors leads to activation of the PI3K/AKT, p38 MAPK, FAK and paxillin. VEGFA/VEGF165 is a heparin-binding protein, which exists as a disulfide-linked homodimer. It induces proliferation and migration of vascular endothelial cells, and is essential for both physiological and pathological angiogenesis. Diseases associated with VEGFA/VEGF165 include microvascular complications of diabetes 1 (MVCD1) and atherosclerosis. It is also related to the integrated Breast Cancer Pathway.

Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute at 0.2-0.3 mg/mL in distilled water is recommended.

NCBI Gene Symbol: VEGFA

Gene ID: 7422

NCBI Accession: P15692