Human CellExp™ TNFRSF6B, Fc Tag, Human Recombinant

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SKU:
P1492-10
€185
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Description

Human CellExp™ TNFRSF6B, Fc Tag, Human Recombinant is available at Gentaur for Next week delivery.

Acts as a decoy receptor that competes with death receptors for ligand binding

Biomolecule/Target:

Alternates names: TNFRSF6B, DCR3, TR6, M68

Synonyms: TNFRSF6B, DCR3, TR6, M68

Background Information: Tumor necrosis factor receptor superfamily member 6B (TNFRSF6B) is also known as Decoy Receptor 3 (DcR3), Decoy receptor for Fas ligand and M68, which belongs to the tumor necrosis factor receptor superfamily. TNFRSF6 is a soluble protein which contains four TNFR-Cys repeats. Unlike most of the other members of TNFR superfamily, TNFRSF6 is a soluble protein which contains no transmembrane domain. TNFRSF6B acts as a decoy receptor that competes with death receptors for ligand binding. The protein is postulated to play a regulatory role in suppressing FasL- and LIGHT-mediated cell death and T cell activation as well as to induce angiogenesis via neutralization of TL1A.

Reconstitution Instructions: Reconstitute in sterile deionized water to the desired protein concentration.

NCBI Gene Symbol: CFD

Gene ID: 8771

NCBI Accession: O95407-1

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Additional Information

Size:
10 µg
Adwords:
False
Country of Manufacturing Origin:
USA
Country of Animal Origin:
USA
Gene Source:
Human
Recombinant:
True
Source:
HEK 293 cells
Purity by SDS-PAGE:
>95%
Endotoxin Level:
Less than 1.0 EU per μg by the LAL method.
Activity (Specifications/test method):
Immobilized Human LIGHT, Mouse IgG2a Fc Tag, low endotoxin at 5 μg/mL (100 μL/well) can bind Human DcR3, Fc Tag with a linear range of 5-20 ng/mL
Molecular Weight:
This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 56.2 kDa. The protein migrates as 65 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Storage Temperature:
-20°C
Shelf Life:
12 months
Appearance:
Lyophilized powder
Handling:
Centrifuge the vial prior to opening.
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