Human CellExp™ TNF-alpha, Human Recombinant

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SKU:
6482-50
€185
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Description

Human CellExp™ TNF-alpha, Human Recombinant is available at Gentaur for Next week delivery.

A potent lymphoid factor that exerts cytotoxic effects on a wide range of cells

Biomolecule/Target:

Alternates names: TNF-alpha, Tumor necrosis factor ligand superfamily member 2, TNF-a, Cachectin, DIF, TNFA, TNFSF2.

Synonyms: Human Cellexp Human Recombinant TNF-alpha

Background Information: Tumor Necrosis Factor-α (TNF-α) is a potent lymphoid factor that exerts cytotoxic effects on a wide range of tumor cells and certain other target cells. TNF is a cytokine involved in systemic inflammation and is a member of a group of cytokines that all stimulate the acute phase reaction. TNF is mainly secreted by macrophages. TNF causes apoptotic cell death, cellular proliferation, differentiation, inflammation, tumorigenesis and viral replication, TNF is also involved in lipid metabolism, and coagulation. TNF's primary role is in the regulation of immune cells. Dysregulation and, in particular, overproduction of TNF have been implicated in a variety of human diseases- autoimmune diseases, insulin resistance, and cancer.

Reconstitution Instructions: Reconstitute in sterile PBS containing 0.1% endotoxin-free recombinant human serum albumin.

NCBI Gene Symbol: TNF

Gene ID: 7124

NCBI Accession: P01375

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Additional Information

Size:
50 µg
Country of Manufacturing Origin:
USA
Country of Animal Origin:
China
Gene Source:
Human
Recombinant:
Yes
Source:
Human 293 cell expressed
Purity by SDS-PAGE:
> 95%
Assay:
SDS-PAGE
Purity:
N/A
Assay 2:
N/A
Endotoxin Level:
< 1.0 EU per 1 μg of protein
Activity (Specifications/test method):
N/A
Biological activity:
ED₅₀ is typically < 0.9 ng/mL. The specific activity was determined by the dose-dependent cytotoxity of the TNF alpha sensitive cell line L-929 in the presence of Actinomycin D.
Results:
< 0.9 ng/ml
Molecular Weight:
17 kDa, non-disulfide bonded homotrimer, glycosylated
Storage Temperature:
-20°C
Shelf Life:
12 months
Concentration:
N/A
Appearance:
Lyophilized
Handling:
Centrifuge the vial prior to opening.
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