BioVision Products
Human CellExp™ SCARB2 /CD36L2 /LIMP2, human recombinant
- SKU:
- 7509-50
Description
Human CellExp™ SCARB2 /CD36L2 /LIMP2, human recombinant is available at Gentaur for Next week delivery.
≥95% pure, active, human cell expressed, human recombinant SCARB2 /CD36L2 /LIMP2 - a lysosomal receptor for glucosylceramidase (GBA) targeting
Biomolecule/Target: SCARB2 /CD36L2 /LIMP2
Alternates names: SCARB2, CD36L2, LIMP2, LIMPII, LGP85, CD36, AMRF, EPM4, HLGP85, SR-BII
Synonyms: SCARB2, CD36L2, LIMP2, LIMPII, LGP85, CD36, AMRF, EPM4, HLGP85, SR-BII
Background Information: Scavenger receptor class B member 2 (SCARB2) is also known as Lysosome membrane protein 2 (LIMP2), 85 kDa lysosomal membrane sialoglycoprotein (LGP85), CD36 antigen-like 2 (CD36L2, LIMP2), which belongs to the CD36 family. SCARB2 acts as a lysosomal receptor for glucosylceramidase (GBA) targeting. It may participate in membrane transportation and the reorganization of endosomal/lysosomal compartment. LIMPII is identified as a receptor for EV71 (human enterovirus species A, Enterovirus 71) and CVA16 (coxsackievirus A16) which are most frequently associated with hand, foot and mouth disease (HFMD). Expression of human LIMP2 enables normally unsusceptible cell lines to support the viruses’ propagation and develop cytopathic effects. In addition, LIMP2 also has been shown to bind thrombospondin-1, may contribute to the pro-adhesive changes of activated platelets during coagulation, and inflammation. Deficiency of the protein in mice impairs cell membrane transport processes and causes pelvic junction obstruction, deafness, and peripheral neuropathy.
Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in PBS, pH 7.4. Do not vortex.
NCBI Gene Symbol: SCARB2
Gene ID: 950
NCBI Accession: Q14108
Additional Information
Size: |
50 μg |
Country of Manufacturing Origin: |
USA |
Country of Animal Origin: |
USA |
Gene Source: |
Human |
Recombinant: |
Yes |
Source: |
HEK293 cells |
Purity by SDS-PAGE: |
≥95% |
Assay: |
SDS-PAGE |
Purity: |
N/A |
Assay 2: |
N/A |
Endotoxin Level: |
<1 EU/μg by LAL method |
Activity (Specifications/test method): |
N/A |
Biological activity: |
Measured by its binding ability in a functional ELISA. Immobilized rh SCARB2 / CD36L2/ LIMP2 Fc Chimera at 5 µg/ml (100 µl/well) can bind rhTSP-2/His with a linear range of 0.1 - 5 µg/ml. |
Results: |
Measured by its binding ability in a functional ELISA. Immobilized rh SCARB2 / CD36L2/ LIMP2 Fc Chimera at 5 µg/ml (100 µl/well) can bind rhTSP-2/His with a linear range of 0.1 - 5 µg/ml. |
Molecular Weight: |
This protein fused with Fc fragment of human IgG1 at the C-terminus, has a calculated MW of 72.5 kDa. The predicted N-terminus is Arg 27. DTT-reduced Protein migrates as 90-115 kDa due to glycosylation. |
Storage Temperature: |
-20°C |
Shelf Life: |
12 months |
Concentration: |
N/A |
Appearance: |
Lyophilized |
Handling: |
Centrifuge the vial prior to opening. |