Human CellExp™ ROR1, Fc Tag, Human Recombinant

Human CellExp™ ROR1, Fc Tag, Human Recombinant is available at Gentaur for Next week delivery.

Receptor for wnt ligand WNT5A

Biomolecule/Target: ROR1

Alternates names: ROR1, NTRKR1

Synonyms: ROR1, NTRKR1

Background Information: Tyrosine-protein kinase transmembrane receptor ROR1 is also known as Neurotrophic tyrosine kinase, receptor-related 1 (NTRKR1), which belongs to the protein kinase superfamily or tyr protein kinase family or ROR subfamily. ROR1 contains 1 FZ (frizzled) domain, 1 Ig-like C2-type (immunoglobulin-like) domain, 1 kringle domain, 1 protein kinase domain. ROR1 is expressed at high levels during early embryonic development. The expression levels drop strongly around day 16 and there are only very low levels in adult tissues. Isoform Short is strongly expressed in fetal and adult CNS and in a variety of human cancers, including those originating from CNS or PNS neuroectoderm. ROR1 could interact with casein kinase 1 epsilon (CK1ε) to activate phosphoinositide 3-kinase-mediated AKT phosphorylation and cAMP-response-element-binding protein (CREB), which was associated with enhanced tumor-cell growth.

Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in distilled water.

NCBI Gene Symbol: ROR1

Gene ID: 4919

NCBI Accession: Q01973