Human CellExp™ Noggin, Human Recombinant

Human CellExp™ Noggin, Human Recombinant is available at Gentaur for Next week delivery.

An inhibitor of TGF-β signal transduction

Biomolecule/Target:

Alternates names: SYM1, SYNS1, NOG.

Synonyms: Human Cellexp Human Recombinant Noggin

Background Information: Noggin belongs to a group of diffusible proteins which bind to ligands of the TGF-β family and regulate their activity by inhibiting their access to signaling receptors. Noggin was originally identified as a BMP-4 antagonist whose action is critical for proper formation of the head and other dorsal structures. Consequently, Noggin has been shown to modulate the activities of other BMPs including BMP-2,-7,-13, and -14. Targeted deletion of Noggin in mice results in prenatal death and recessive phenotype displaying a severely malformed skeletal system. Conversely, transgenic mice over-expressing Noggin in mature osteoblasts display impaired osteoblastic differentiation, reduced bone formation, and severe osteoporosis.

Reconstitution Instructions: Reconstitute in sterile PBS containing 0.1% endotoxin-free recombinant human serum albumin.

NCBI Gene Symbol: NOG

Gene ID: 9241

NCBI Accession: Q13253