Human CellExp™ NKG2D / CD314, Fc Tag, Human Recombinant

Human CellExp™ NKG2D / CD314, Fc Tag, Human Recombinant is available at Gentaur for Next week delivery.

Plays a role as a receptor for the recognition of MHC class I HLA-E molecules

Biomolecule/Target:

Alternates names: NKG2D, CD314, KLRK1, NK cell receptor D

Synonyms: NKG2D, CD314, KLRK1, NK cell receptor D

Background Information: NKG2D is a transmembrane protein belonging to the CD94/NKG2 family of C-type lectin-like receptors, also known as KLRK1, CD314, D12S2489E, KLR and killer cell lectin like receptor K1. NKG2D itself forms a homodimer whose ectodomains serve for ligand binding. NKG2D is a major recognition receptor for the detection and elimination of transformed and infected cells as its ligands are induced during cellular stress, either as a result of infection or genomic stress such as in cancer. In NK cells, NKG2D serves as an activating receptor, which itself is able to trigger cytotoxicity. The function of NKG2D on CD8+ T cells is to send co-stimulatory signals to activate them.

Reconstitution Instructions: Reconstitute in sterile deionized water to the desired protein concentration.

NCBI Gene Symbol: KLRK1

Gene ID: 22914

NCBI Accession: P26718-1