BioVision Products
Human CellExp™ MSR1/CD204, human recombinant
- SKU:
- 7390-50
Description
Human CellExp™ MSR1/CD204, human recombinant is available at Gentaur for Next week delivery.
Mediates the endocytosis of modified low density lipoproteins (LDLs)
Biomolecule/Target: MSR1/CD204
Alternates names: MSR1, CD204, SCARA1, SR-A, phSR1, phSR2
Synonyms: MSR1, CD204, SCARA1, SR-A, phSR1, phSR2
Background Information: Macrophage scavenger receptor 1 (MSR1) also known as CD204, SCARA1, SR-A, and is class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. Defects in MSR1 may be a cause of prostate cancer (PC) or Barrett esophagus (BE).
Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 µg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.
NCBI Gene Symbol: MSR1
Gene ID: 4481
NCBI Accession: P21757
Additional Information
Size: |
50 μg |
Country of Manufacturing Origin: |
USA |
Country of Animal Origin: |
USA |
Gene Source: |
Human |
Recombinant: |
Yes |
Source: |
HEK293 cells |
Purity by SDS-PAGE: |
≥95% |
Assay: |
SDS-PAGE |
Purity: |
N/A |
Assay 2: |
N/A |
Endotoxin Level: |
<1 EU/μg by LAL method |
Activity (Specifications/test method): |
N/A |
Biological activity: |
Measured by its binding ability in a functional ELISA. Immobilized rhMSR1 at 5 µg/ml (100 µl/well) can bind biotinylated advanced glycation end products of bovine serum albumin (AGE-BSA, Cat # 2221-10) with a linear range of 1 - 150 ng/ml. |
Results: |
Measured by its binding ability in a functional ELISA. Immobilized rhMSR1 at 5 µg/ml (100 µl/well) can bind biotinylated advanced glycation end products of bovine serum albumin (AGE-BSA, Cat # 2221-10) with a linear range of 1 - 150 ng/ml. |
Molecular Weight: |
This protein is fused with 6×His tag at the C-terminus, has a calculated MW of 42.1 kDa. The predicted N-terminus is Lys 77. DTT-reduced Protein migrates as 65-72 kDa due to glycosylation. |
Storage Temperature: |
-20°C |
Shelf Life: |
12 months |
Concentration: |
N/A |
Appearance: |
Lyophilized |
Handling: |
Centrifuge the vial prior to opening. |