Human CellExp™LRP-5, Fc tag, Human Recombinant

Human CellExp™LRP-5, Fc tag, Human Recombinant is available at Gentaur for Next week delivery.

Frizzled protein family members that plays a key role in skeletal homeostasis

Biomolecule/Target:

Alternates names: LRP-5, LRP-5, LRP-7, LRP7, LR3

Synonyms: LRP-5, LRP-5, LRP-7, LRP7, LR3

Background Information: Low-density lipoprotein receptor-related protein 5(LRP-5) is also known as BMND1, EVR1, EVR4, HBM, LR3, LRP7, OPPG, OPTA1, VBCH2, LDL receptor related protein 5 and PCLD4. LRP5 is a transmembrane low-density lipoprotein receptor that shares a similar structure with LRP6. LRP5 acts as a co-receptor with LRP6 and the Frizzled protein family members for transducing signals by Wnt proteins through the canonical Wnt pathway. This protein plays a key role in skeletal homeostasis. Mutations in LRP5 can lead to considerable changes in bone mass. A loss-of-function mutation causes osteoporosis-pseudoglioma (decrease in bone mass), while a gain-of-function mutation causes drastic increases in bone mass.

Reconstitution Instructions: Reconstitute in sterile deionized water to the desired protein concentration.

NCBI Gene Symbol: LRP5

Gene ID: 4041

NCBI Accession: O75197-1