Human CellExp™ LIFR /CD118, human recombinant

Human CellExp™ LIFR /CD118, human recombinant is available at Gentaur for Next week delivery.

A polyfunctional cytokine that affects the differentiation, survival, and proliferation of a wide variety of cells

Biomolecule/Target: LIFR /CD118

Alternates names: LIFR, CD118, FLJ98106, FLJ99923, LIF-R, SJS2, STWS, SWS, Leukemia inhibitory factor receptor, Cluster of Differentiation 118

Synonyms: LIFR, CD118, FLJ98106, FLJ99923, LIF-R, SJS2, STWS, SWS, Leukemia inhibitory factor receptor, Cluster of Differentiation 118

Background Information: Leukemia inhibitory factor receptor also known as LIFR; CD118; FLJ98106; FLJ99923; LIF-R; SJS2; STWS; SWS, is the receptor for leukemia inhibitory factor (LIF). The leukemia inhibitory factor is a polyfunctional cytokine that affects the differentiation, survival, and proliferation of a wide variety of cells in the adult and the embryo. LIF action appears to be mediated through a high-affinity receptor complex composed of a low-affinity LIF binding chain (LIF receptor) and a high-affinity converter subunit, gp130. Both LIFR and gp130 are members of a family of cytokine receptors that includes components of the receptors for the majority of hematopoietic cytokines and for cytokines that affect other systems, including the ciliary neurotrophic factor, growth hormone and prolactin Defects in LIFR are the cause of Stueve-Wiedemann syndrome (SWS), a severe autosomal recessive condition and belongs to the group of the bent-bone dysplasias.

Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 µg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.

NCBI Gene Symbol: LIFR

Gene ID: 3977

NCBI Accession: P42702