Human CellExp™ Integrin alpha V beta 5 Heterodimer, Human recombinant

Human CellExp™ Integrin alpha V beta 5 Heterodimer, Human recombinant is available at Gentaur for Next week delivery.

Biomolecule/Target: ITGAV, ITGB5

Alternates names: Integrin alpha V beta 5, ITGAVB5, ITGAV & ITGB6

Synonyms: Integrin alpha V beta 5, ITGAVB5, ITGAV & ITGB6

Background Information: Integrin alpha V beta 5 (ITGAV & ITGB5 or ITGAVB5) is expressed on a wide variety of cell types including keratinocytes, fibroblasts, adhesive monocytes, embryonic stem cells, and select endothelium and epithelium. ITGAV & ITGB5 binds ligands containing an RGD motif, notably vitronectin. Growth factors that increase PKC activity, such as VEGF or TGF alpha, promote ITGAVB5-mediated angiogenesis while alpha V beta 3, which may be expressed in the same cell, responds to FGF-basic and TNF alpha. An inhibitor of both down regulates tumor angiogenesis. During lung inflammation, up regulation of ITGAVB5 on myofibroblasts or infiltrating lymphocytes may contribute to fibrosis by freeing TGF beta from latency.

Reconstitution Instructions: Reconstitute in sterile deionized water to the desired protein concentration.

NCBI Gene Symbol: ITGAV, ITGB5

Gene ID: 3685, 3693

NCBI Accession: P06756, P18084