Human CellExp™ IL-6 Rα, Human Recombinant

Human CellExp™ IL-6 Rα, Human Recombinant is available at Gentaur for Next week delivery.

A type I cytokine receptor

Biomolecule/Target: IL-6 Rα

Alternates names: soluble IL-6 receptor alpha, B cell stimulatory factor-2, CD126

Synonyms: soluble IL-6 receptor alpha, B cell stimulatory factor-2, CD126

Background Information: IL-6 mediates its biological effects through the type I IL-6 receptor system that consists of two chains, IL-6Rα and gp130. The IL-6Rα chain is the binding component specific to IL-6; while the gp130 only transmits signals of IL-6 when bound to IL-6Rα. The gp130 also can transmit signals from LIF, OSM, CNTF, IL-11 and CT-1 in conjunction with other receptor subunits. The low-affinity binding site for IL-6 is composed of IL-6Rα alone. IL-6Rα is expressed in a wide range of cells including T cells, fibroblasts and macrophages. Soluble IL-6Rα which consists of only the extracellular domain of the IL-6Rα chain, acts as an agonist of IL-6 activity at low concentrations. Recombinant human sIL-6Rα is a 37.6 kDa protein consisting of the extracellular domain of the IL-6Rα chain (339 amino acid residues).

Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in 1x PBS, pH 7.2 to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.

NCBI Gene Symbol: IL6RA

Gene ID: 3570

NCBI Accession: P08887