Human CellExp™ IL-23 R, Fc Tag, Human recombinant

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SKU:
P1425-50
€185
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Description

Human CellExp™ IL-23 R, Fc Tag, Human recombinant is available at Gentaur for Next week delivery.

Biomolecule/Target:

Alternates names: IL23R, IL-23 Receptor, Interleukin-23 receptor

Synonyms: IL23R, IL-23 Receptor, Interleukin-23 receptor

Background Information: Interleukin 23 receptor (IL-23R) is a type I cytokine receptor, and IL-23R pairs with the receptor molecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling. Also, IL-23R associates constitutively with Janus kinase 2 (JAK2), and binds to transcription activator STAT3 in a ligand-dependent manner. Furthermore, IL-23R mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. As for IL-23, it may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis.

Reconstitution Instructions: Reconstitute in sterile deionized water to the desired protein concentration.

NCBI Gene Symbol: IL23R

Gene ID: 149233

NCBI Accession: Q5VWK5

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Additional Information

Size:
50 µg
Adwords:
False
Country of Manufacturing Origin:
USA
Country of Animal Origin:
USA
Gene Source:
Human
Recombinant:
True
Source:
HEK 293 Cells
Purity by SDS-PAGE:
>95%
Assay:
SDS-PAGE
Endotoxin Level:
Less than 1.0 EU per μg by the LAL method.
Activity (Specifications/test method):
Immobilized Biotinylated Human IL23A & IL12B, His Tag, Avi Tag at 2 μg/ml (100 μl/well) on streptavidin precoated (0.2 μg/well) plate, can bind Human IL-23 R, Fc Tag with a linear range of 0.4-6 ng/ml
Biological activity:
Captured Human IL-23 R, Fc Tag on CM5 chip via anti-human IgG Fc antibodies surface can bind Human IL23A & IL12B, His Tag with an affinity constant of 5.36 nM as determined in a SPR assay.
Molecular Weight:
This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 64.5 kDa. The protein migrates as 90-100 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Storage Temperature:
-20ºC
Shelf Life:
12 months
Appearance:
Powder
Handling:
Centrifuge the vial prior to opening.
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