Human CellExp™ IL-15 R alpha / CD215, Fc Tag, Human recombinant

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SKU:
P1424-50
€185
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Description

Human CellExp™ IL-15 R alpha / CD215, Fc Tag, Human recombinant is available at Gentaur for Next week delivery.

High-affinity receptor for interleukin-15.

Biomolecule/Target:

Alternates names: IL15RA, IL-15RA, IL-15R-alpha, IL-15 receptor subunit alpha

Synonyms: IL15RA, IL-15RA, IL-15R-alpha, IL-15 receptor subunit alpha

Background Information: IL15R is a heterotrimer of IL15RA, IL2RB and IL2RG. IL-15RA, also known as CD215, IL-15 R alpha, is a widely expressed 60 kDa transmembrane glycoprotein. High-affinity receptor for interleukin-15. Can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells. Expression of different isoforms may alter or interfere with signal transduction. An interleukin (IL)-15 superagonist/IL-15 receptor α fusion complex (IL-15SA/IL-15RA; ALT-803) activates the IL-15 receptor on CD8 T cells and NK cells, and has shown significant anti-tumor. Signal transduction involves SYK. Higher levels of soluble sIL-15RA form in comparison with membrane-bound forms is present in all brain structures.

Reconstitution Instructions: Reconstitute in sterile deionized water to the desired protein concentration.

NCBI Gene Symbol: IL15RA

Gene ID: Q13261

NCBI Accession: Q13261

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Additional Information

Size:
50 µg
Adwords:
False
Country of Manufacturing Origin:
USA
Country of Animal Origin:
USA
Gene Source:
Human
Recombinant:
False
Source:
HEK 293 Cells
Purity by SDS-PAGE:
>95%
Assay:
SDS-PAGE
Endotoxin Level:
Less than 1.0 EU per μg by the LAL method.
Activity (Specifications/test method):
Immobilized Human IL-15 R alpha, Fc Tag at 2 μg/ml (100 μl/well) can bind Biotinylated Human IL-15 with a linear range of 2-78 ng/ml.
Molecular Weight:
This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 44.8 kDa. The protein migrates as 60-80 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Storage Temperature:
-20°C
Shelf Life:
12 months
Appearance:
Lyophilized powder
Handling:
Centrifuge the vial prior to opening.
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