Human CellExp™ IL-12B & IL-12A Heterodimer, Human Recombinant

Human CellExp™ IL-12B & IL-12A Heterodimer, Human Recombinant is available at Gentaur for Next week delivery.

T cell-stimulating factor

Biomolecule/Target: IL12B, IL12A

Alternates names: IL12, p70, Interleukin-12

Synonyms: IL12, p70, Interleukin-12

Background Information: Interleukin 12 (IL12) is also known as p70, and is an interleukin that is naturally produced by dendritic cells, macrophages and human B-lymphoblastoid cells (NC-37) in response to antigenic stimulation.IL12 is a heterodimeric cytokine, containing IL-12A (p35) and IL-12B (p40). IL-12 is involved in the differentiation of naive T cells into Th1 cells. It is known as a T cell-stimulating factor, which can stimulate the growth and function of T cells. It stimulates the production of IFN-γ and TNF-α from T cells and NK cells, and reduces IL-4 mediated suppression of IFN-γ. IL-12 plays an important role in the activities of natural killer cells and T lymphocytes. IL-12 also has anti-angiogenic activity, which means it can block the formation of new blood vessels.

Reconstitution Instructions: Reconstitute in sterile deionized water to the desired protein concentration.

NCBI Gene Symbol: IL12B, IL12A

Gene ID: 3593, 3592

NCBI Accession: P29460, P29459