Human CellExp™ HDAC8, Human Recombinant, Active

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SKU:
P1266-50
€185
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Description

Human CellExp™ HDAC8, Human Recombinant, Active is available at Gentaur for Next week delivery.

Critical regulator of transcription, cell cycle progression, and developmental events

Biomolecule/Target: HDAC8

Alternates names: HDACL1, HD8, Histone Deacetylase 8, CDA07

Synonyms: HDACL1, HD8, Histone Deacetylase 8, CDA07

Background Information: Human Histone Deacetylase 8 (HDAC8) is a member of the class I Histone Deacetylases. HDACs are important enzymes for the transcriptional regulation of gene expression in eukaryotic cells. HDACs catalyze the removal of acetyl groups from lysines near the N-termini of histones. Human HDACs have been implicated in a variety of human diseases such as cardiomyopathy, osteodystrophy, neurodegenerative disorders, aging and cancer. Expression of HDAC8 is restricted to cells showing smooth muscle differentiation in normal human tissue and is a novel marker of smooth muscle differentiation. Like other class I and II HDAC members, the activity of HDAC8 is sensitive to HDAC inhibitor Trichostatin A (TSA).

Reconstitution Instructions: N/A

NCBI Gene Symbol: HDAC8

Gene ID: 55869

NCBI Accession: Q9BY41

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Additional Information

Size:
50 μg
Country of Manufacturing Origin:
USA
Country of Animal Origin:
USA
Gene Source:
Human
Recombinant:
Yes
Source:
HEK293 cells
Purity by SDS-PAGE:
≥95%
Assay:
SEC
Purity:
N/A
Assay 2:
N/A
Endotoxin Level:
N/A
Activity (Specifications/test method):
Deacetylation activity was determined using the Boc-K(TFA)-AMC substrate.
Biological activity:
N/A
Results:
N/A
Molecular Weight:
41 kDa
Storage Temperature:
-80°C
Shelf Life:
12 months
Concentration:
N/A
Appearance:
Liquid
Handling:
Thaw on ice, and aliquot into smaller working quantities to avoid multiple freeze/thaw cycles.
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