Human CellExp™ HDAC8, Human Recombinant, Active

Human CellExp™ HDAC8, Human Recombinant, Active is available at Gentaur for Next week delivery.

Critical regulator of transcription, cell cycle progression, and developmental events

Biomolecule/Target: HDAC8

Alternates names: HDACL1, HD8, Histone Deacetylase 8, CDA07

Synonyms: HDACL1, HD8, Histone Deacetylase 8, CDA07

Background Information: Human Histone Deacetylase 8 (HDAC8) is a member of the class I Histone Deacetylases. HDACs are important enzymes for the transcriptional regulation of gene expression in eukaryotic cells. HDACs catalyze the removal of acetyl groups from lysines near the N-termini of histones. Human HDACs have been implicated in a variety of human diseases such as cardiomyopathy, osteodystrophy, neurodegenerative disorders, aging and cancer. Expression of HDAC8 is restricted to cells showing smooth muscle differentiation in normal human tissue and is a novel marker of smooth muscle differentiation. Like other class I and II HDAC members, the activity of HDAC8 is sensitive to HDAC inhibitor Trichostatin A (TSA).

Reconstitution Instructions: N/A

NCBI Gene Symbol: HDAC8

Gene ID: 55869

NCBI Accession: Q9BY41