Human CellExp™ GFRA2 /GDNFRB, human recombinant

Human CellExp™ GFRA2 /GDNFRB, human recombinant is available at Gentaur for Next week delivery.

Involved in the initiation of the RET signaling pathway

Biomolecule/Target: GFRA2 /GDNFRB

Alternates names: GFRA2, GDNFRB, NRTNR-ALPHA, NTNRA, RETL2, TRNR2.

Synonyms: GFRA2, GDNFRB, NRTNR-ALPHA, NTNRA, RETL2, TRNR2.

Background Information: GDNF family receptor alpha-2 (GFRA2) also known as GDNF receptor beta, Neurturin receptor alpha, RET ligand 2, TGF-beta-related neurotrophic factor receptor 2, is a cell membrane protein which belongs to the GDNFR family. Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. GDNF is a glycosylated, disulfide-bonded homodimer that is distantly related to the TGF-beta superfamily of growth factors. Three receptors for these factors, GFRα-1, GFRα-2 and GFRα-3 have been identified. The isoform 1 of GFRA2 is found in both brain and placenta. GFRA2 mediates the NRTN-induced autophosphorylation and activation of the RET receptor and also able to mediate GDNF signaling through the RET tyrosine kinase receptor. GFRA2 mediates the NRTN-induced autophosphorylation and activation of the RET receptor. It can also mediate GDNF signaling through the RET tyrosine kinase receptor.

Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 µg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.

NCBI Gene Symbol: GFRA2

Gene ID: 2675

NCBI Accession: O00451