BioVision Products
Human CellExp™ Decorin /Bone proteoglycan II, human recombinant
- SKU:
- 7449-20
Description
Human CellExp™ Decorin /Bone proteoglycan II, human recombinant is available at Gentaur for Next week delivery.
A protein which binds to type I collagen fibrils, and plays a role in matrix assembly
Biomolecule/Target: Decorin /Bone proteoglycan II
Alternates names: Decorin, DCN, CSCD, DSPG2, PG40, PGII, PGS2, SLRR1B.
Synonyms: Decorin, DCN, CSCD, DSPG2, PG40, PGII, PGS2, SLRR1B.
Background Information: Decorin, also known as bone proteoglycan II, PGS2, SLRR1B, DCN, DSPG2 and PG40, is a secreted chondroitin /dermatan sulfate proteoglycan in the family of small leucine-rich proteoglycans (SLRPs). Decorin is a small cellular or pericellular matrix proteoglycan and is closely related in structure to biglycan protein. Decorin and biglycan are thought to be the result of gene duplication. This protein is a component of connective tissue, binds to type I collagen fibrils, and plays a role in matrix assembly. Decorin appears to influence fibrillogenesis, and also interacts with fibronectin, thrombospondin, the complement component C1q, epidermal growth factor receptor (EGFR) and transforming growth factor-beta (TGF-beta). Defects in DCN are the cause of congenital stromal corneal dystrophy (CSCD).
Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 µg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.
NCBI Gene Symbol: DCN
Gene ID: 1634
NCBI Accession: P07585
Additional Information
Size: |
20 μg |
Country of Manufacturing Origin: |
USA |
Country of Animal Origin: |
USA |
Gene Source: |
Human |
Recombinant: |
Yes |
Source: |
HEK293 cells |
Purity by SDS-PAGE: |
≥95% |
Assay: |
SDS-PAGE |
Purity: |
N/A |
Assay 2: |
N/A |
Endotoxin Level: |
<1 EU/μg by LAL method |
Activity (Specifications/test method): |
N/A |
Biological activity: |
Measured by its ability to modulate collagen fibrillogenesis. At 5 µg/mL, rh Decorin can significantly delay the rate of type I collagen fibrillogenesis. |
Results: |
Measured by its ability to modulate collagen fibrillogenesis. At 5 µg/mL, rh Decorin can significantly delay the rate of type I collagen fibrillogenesis. |
Molecular Weight: |
This protein fused with 6×His tag at the C-terminus, has a calculated MW of 38.8 kDa. The predicted N-terminus is Gly 17. DTT-reduced Protein migrates as 45 kDa or higher due to different glycosylation. |
Storage Temperature: |
-20°C |
Shelf Life: |
12 months |
Concentration: |
N/A |
Appearance: |
Lyophilized |
Handling: |
Centrifuge the vial prior to opening. |