Human CellExp™ Complement C5, Human Recombinant

Human CellExp™ Complement C5, Human Recombinant is available at Gentaur for Next week delivery.

a potent chemotactic factor for human peripheral blood neutrophils and monocytes

Biomolecule/Target:

Alternates names: Complement C5, C5, CPAMD4

Synonyms: Complement C5, C5, CPAMD4

Background Information: Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. C5 precursor is first processed by the removal of 4 basic residues, forming two chains, beta and alpha, linked by a disulfide bond. C5 convertase activates C5 by cleaving the alpha chain, releasing C5a anaphylatoxin and generating C5b (beta chain + alpha' chain). Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled. The C5a anaphylatoxin interacts with C5AR1 and tick complement inhibitor. C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation.

Reconstitution Instructions: Reconstitute in sterile deionized water to the desired protein concentration.

NCBI Gene Symbol: C3

Gene ID: 718

NCBI Accession: P01031-1