Human CellExp™ Complement C5, Cynomolgus Recombinant

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SKU:
P1414-100
€185
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Description

Human CellExp™ Complement C5, Cynomolgus Recombinant is available at Gentaur for Next week delivery.

A potent chemokine which stimulates the locomotion of polymorphonuclear leukocyte

Biomolecule/Target:

Alternates names: Complement C5,C5,CPAMD4

Synonyms: Complement C5,C5,CPAMD4

Background Information: Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. C5 precursor is first processed by the removal of 4 basic residues, forming two chains, beta and alpha, linked by a disulfide bond. C5 convertase activates C5 by cleaving the alpha chain, releasing C5a anaphylatoxin and generating C5b (beta chain + alpha' chain). Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled. The C5a anaphylatoxin interacts with C5AR1 and tick complement inhibitor. C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation.

Reconstitution Instructions: Reconstitute in sterile deionized water to the desired protein concentration.

NCBI Gene Symbol:

Gene ID:

NCBI Accession: XP_005580972.1

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Additional Information

Size:
100 µg
Adwords:
False
Country of Manufacturing Origin:
USA
Country of Animal Origin:
USA
Gene Source:
Cynomolgus
Recombinant:
False
Source:
human 293 cells (HEK293)
Purity by SDS-PAGE:
>95%
Assay:
SDS-PAGE
Endotoxin Level:
Less than 1.0 EU per μg by the LAL method
Activity (Specifications/test method):
Immobilized Cynomolgus Complement C5, His Tag at 2 μg/ml (100 μl/well) can bind Anti-C5a (Human IgG1) with a linear range of 0.4-6 ng/ml.
Molecular Weight:
This protein carries a polyhistidine tag at the C-terminus. The mature form of Complement C5 is a disulfide-linked heterodimer composed of proteolytically cleaved α and β chain. Each α and β chain has a calculated MW of 73.3 kDa (β chain) and 114.9 k
Storage Temperature:
-20°C
Shelf Life:
12 months
Appearance:
Sterile Filtered colorless solution
Handling:
Centrifuge the vial prior to opening.
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