BioVision Products
Human CellExp™ CD84 / SLAMF5, human recombinant
- SKU:
- 7378-50
Description
Human CellExp™ CD84 / SLAMF5, human recombinant is available at Gentaur for Next week delivery.
Increases the proliferative responses of activated T-cells
Biomolecule/Target: CD84/SLAMF5
Alternates names: CD84, SLAMF5, LY9B, SLAMF5, hCD84, mCD84
Synonyms: CD84, SLAMF5, LY9B, SLAMF5, hCD84, mCD84
Background Information: Leukocyte differentiation antigen CD84 is also known as SLAM family member 5 (SLAMF5), which belongs to immunoglobulin (Ig) superfamily. CD84 / SLAMF5 contain one Ig-like C2-type (immunoglobulin-like) domain. CD84 plays a role as adhesion receptor functioning by homophilic interactions and by clustering. CD84 / SLAMF5 increases proliferative responses of activated T-cells and SH2D1A/SAP does not seen be required for this process. Homophilic interactions enhance interferon gamma/IFNG secretion in lymphocytes and induce platelet stimulation via a SH2D1A/SAP-dependent pathway.
Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 µg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.
NCBI Gene Symbol: CD84
Gene ID: 8832
NCBI Accession: Q9UIB8
Additional Information
Size: |
50 μg |
Country of Manufacturing Origin: |
USA |
Country of Animal Origin: |
USA |
Gene Source: |
Human |
Recombinant: |
Yes |
Source: |
HEK293 cells |
Purity by SDS-PAGE: |
≥95% |
Assay: |
SDS-PAGE |
Purity: |
N/A |
Assay 2: |
N/A |
Endotoxin Level: |
<1 EU/μg by LAL method |
Activity (Specifications/test method): |
N/A |
Biological activity: |
Measured in a cell proliferation assay using PHA stimulated human T cells in the presence of anti-CD3. The ED50 for this effect is typically 2-6 µg/ml in the presence of anti-CD3 immobilized at 20 ng/ml. |
Results: |
Measured in a cell proliferation assay using PHA stimulated human T cells in the presence of anti-CD3. The ED50 for this effect is typically 2-6 µg/ml in the presence of anti-CD3 immobilized at 20 ng/ml. |
Molecular Weight: |
This protein is fused with 6×His tag at the C-terminus, has a calculated MW of 23.6 kDa. The predicted N-terminus is Lys 22. DTT-reduced Protein migrates as 35-45 kDa due to glycosylation. |
Storage Temperature: |
-20°C |
Shelf Life: |
12 months |
Concentration: |
N/A |
Appearance: |
Lyophilized |
Handling: |
Centrifuge the vial prior to opening. |