Human CellExp™ CD33/SIGLEC-3

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SKU:
P1616-50
€185
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Description

Human CellExp™ CD33/SIGLEC-3 is available at Gentaur for Next week delivery.

Human recombinant with Fc & His Tag

Biomolecule/Target:

Alternates names: gp67; Siglec-3; CD33; Sialic acid binding Ig-like lectin 3; Myeloid cell surface antigen CD33

Synonyms: gp67; Siglec-3; CD33; Sialic acid binding Ig-like lectin 3; Myeloid cell surface antigen CD33

Background Information: CD33 is a member of the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family. This single-pass type I membrane protein contains one Ig-like C2-type (immunoglobulin-like) domain and one Ig-like Vtype (immunoglobulin-like) domain. It is considered myeloid-specific, but it can also be found on some lymphoid cells. It binds to α2-6- and α2-3-sialylated glycans and sialylated ligands. It acts as an inhibitory receptor since, when it is crosslinked, it becomes phosphorylated on its cytoplasmic ITIM sequence that recruits SHP-1 and SHP-2 phosphatases and negatively regulates cell activation in both myeloid cell lines and activated NK cells. It induces apoptosis in acute myeloid leukemia and is a target for the treatment of leukemia.

Reconstitution Instructions: Reconstitute to a concentration of 0.1-0.5 mg/ml in sterile distilled water.

NCBI Gene Symbol:

Gene ID: 945

NCBI Accession: P20138; NP_001763.3

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Additional Information

Size:
50 μg
Adwords:
FAUX
Country of Manufacturing Origin:
USA
Country of Animal Origin:
N/A
Gene Source:
Human
Recombinant:
VRAI
Source:
HEK293 cells
Purity by SDS-PAGE:
≥ 97% by SDSPAGE
Endotoxin Level:
< 0.1 EU/μg of the protein as determined by LAL method.
Biological activity:
The activity was measured by the binding ability in a functional ELISA. Immobilized Human CD33 at 2 μg/ml (100 μl/well) can bind Anti-Human CD33 Antibody in the linear range of 8-20 ng/ml.
Molecular Weight:
The protein migrates as a band at 70 kDa (Fc and 6×His tag at the C-terminus).
Storage Temperature:
-20ºC
Shelf Life:
12 months
Appearance:
Lyophilized protein
Handling:
Centrifuge the vial prior to opening.
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