Human CellExp™ CD304 / NRP1 / Neurophilin-1, Fc Tag, mouse recombinant

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SKU:
P1409-50
€185
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Description

Human CellExp™ CD304 / NRP1 / Neurophilin-1, Fc Tag, mouse recombinant is available at Gentaur for Next week delivery.

A receptor involved in the development of the cardiovascular system

Biomolecule/Target:

Alternates names: NRP1, Neuropilin-1, NRP, VEGF165R, CD304

Synonyms: NRP1, Neuropilin-1, NRP, VEGF165R, CD304

Background Information: Neuropilin-1 (NRP1) is also known as Vascular endothelial cell growth factor 165 receptor (VEGF165R), CD antigen CD304, which belongs to the neuropilin family. The membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, The PLGF-2 isoform of PGF, The VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis. The soluble isoform 2 binds VEGF-165 and appears to inhibit its binding to cells.

Reconstitution Instructions: Reconstitute in sterile deionized water to the desired protein concentration.

NCBI Gene Symbol: Nrp1

Gene ID: 18186

NCBI Accession: P97333-1

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Additional Information

Size:
50 µg
Adwords:
False
Country of Manufacturing Origin:
USA
Country of Animal Origin:
USA
Gene Source:
Mouse
Recombinant:
True
Source:
HEK 293 cells
Purity by SDS-PAGE:
>90%
Assay:
SDS-PAGE
Endotoxin Level:
Less than 0.1 EU per μg by the LAL method.
Activity (Specifications/test method):
Immobilized Human VEGF165, Tag Free at 2 μg/mL (100 μL/well) can bind Mouse NRP1, Mouse IgG2a Fc Tag with a linear range of 0.5-4 ng/mL
Molecular Weight:
This protein carries a mouse IgG2a Fc tag at the C-terminus. The protein has a calculated MW of 120.5 kDa. The protein migrates as 125 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Storage Temperature:
-20°C
Shelf Life:
12 months
Appearance:
Lyophilized powder
Handling:
Centrifuge the vial prior to opening.
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