BioVision Products
Human CellExp™ CD244 / 2B4 / SLAMF4, human recombinant
- SKU:
- 7374-50
Description
Human CellExp™ CD244 / 2B4 / SLAMF4, human recombinant is available at Gentaur for Next week delivery.
Modulates receptor-ligand interactions to enhance leukocyte activation
Biomolecule/Target: CD244/2B4/SLAMF4
Alternates names: CD244, 2B4, SLAMF4, NKR2B4, NAIL, h2B4
Synonyms: CD244, 2B4, SLAMF4, NKR2B4, NAIL, h2B4
Background Information: Natural killer cell receptor 2B4 is also known as NK cell type I receptor protein 2B4 (NKR2B4 or h2B4), SLAM family member 4 (SLAMF4), Signaling lymphocytic activation molecule 4, CD antigen CD244. NKR2B4 / CD244 contain two Ig-like (immunoglobulin-like) domains. CD244 is expressed in spleen, PBL, followed by lung, liver, testis and small intestine. CD244 interacts with CD48. Following phosphorylation, CD244 is able to recruit PTPN11/SHP-2 and SH2D1A/SAP. SLAMF4 modulate other receptor-ligand interactions to enhance leukocyte activation. CD244/2B4 is the only heterophilic receptor of SLAM family.
Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 µg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.
NCBI Gene Symbol: CD244
Gene ID: 51744
NCBI Accession: Q9BZW8
Additional Information
Size: |
50 μg |
Country of Manufacturing Origin: |
USA |
Country of Animal Origin: |
USA |
Gene Source: |
Human |
Recombinant: |
Yes |
Source: |
HEK293 cells |
Purity by SDS-PAGE: |
≥95% |
Assay: |
SDS-PAGE |
Purity: |
N/A |
Assay 2: |
N/A |
Endotoxin Level: |
<1 EU/μg by LAL method |
Activity (Specifications/test method): |
N/A |
Biological activity: |
Measured by its binding ability in a functional ELISA. Immobilized rh CD244 / 2B4 at 2 μg/ml (100 μl/well) can bind human CD48. The EC50 of human CD48 is 0.39 μg/ml. |
Results: |
Measured by its binding ability in a functional ELISA. Immobilized rh CD244 / 2B4 at 2 μg/ml (100 μl/well) can bind human CD48. The EC50 of human CD48 is 0.39 μg/ml. |
Molecular Weight: |
This protein is fused with polyhistidine tag at the C-terminus, and has a calculated MW of 23.1 kDa. The predicted N-terminus is Cys 22. DTT-reduced Protein migrates as 40-50 kDa due to glycosylation. |
Storage Temperature: |
-20°C |
Shelf Life: |
12 months |
Concentration: |
N/A |
Appearance: |
Lyophilized |
Handling: |
Centrifuge the vial prior to opening. |