Human CellExp™ CD19, Fc Tag, Rhesus macaque recombinant

Human CellExp™ CD19, Fc Tag, Rhesus macaque recombinant is available at Gentaur for Next week delivery.

B-lymphocyte antigen CD19

Biomolecule/Target: CD19

Alternates names: CD19, B4, CVID3, MGC12804

Synonyms: CD19, B4, CVID3, MGC12804

Background Information: B-lymphocyte antigen CD19 (CD19) is also known as B-lymphocyte surface antigen B4, Differentiation antigen CD19 and T-cell surface antigen Leu-12, which is a single-pass type I membrane protein and contains two Ig-like C2-type (immunoglobulin-like) domains. CD19 forms a complex with CD21, CD81 and CD225 in the membrane of mature B cells. CD19 interacts with GRB2 and SOS when phosphorylated on Tyr-348 and/or Tyr-378. CD19 also interacts with PLCG2 when phosphorylated on Tyr-409. CD19 is an important pan B cell marker and co-stimulatory protein in humans and mice. CD19 is a hallmark differentiation antigen of the B cell lineage and positively regulates antigen receptor signal transduction in mature B cells. CD19 defines signaling thresholds for the Ag receptor as well as other cell surface receptors that regulate B lymphocyte selection, activation, and differentiation. Defects in CD19 are a cause of hypogammaglobulinemia.

Reconstitution Instructions: Reconstitute in sterile deionized water to a concentration of 50 μg/ml.

NCBI Gene Symbol: CD19

Gene ID: 705211

NCBI Accession: F7F486