HDAC6, human recombinant

HDAC6, human recombinant is available at Gentaur for Next week delivery.

Regulates the acetylation status of non-histone substrates

Biomolecule/Target: HDAC6

Alternates names: KIAA0901, JM21, HD6

Synonyms: KIAA0901, JM21, HD6

Background Information: HDAC6 is a Class II HDAC. It is unique among human HDACs in having two full deacetylase domains. As a tubulin deacetylase, HDAC6 may act to promote autophagic clearing of Huntington aggregates and retard HIV1 infection. It can shuttle between the nucleus and cytoplasm, suggesting potential extra nuclear functions by regulating the acetylation status of non-histone substrates. By modifying chromatin structure and other non-histone proteins, HDACs play important roles in controlling complex biological events, including cell development, differentiation, programmed cell death, angiogenesis, and inflammation. Considering these major roles, it is conceivable that dysregulation of HDACs and subsequent imbalance of acetylation and deacetylation may be involved in the pathogenesis of various diseases, including cancer and inflammatory diseases.

Reconstitution Instructions: N/A

NCBI Gene Symbol: HDAC6

Gene ID: 10013

NCBI Accession: Q9UBN7