GSK-3β, human recombinant

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SKU:
7004-1000
$183
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Description

GSK-3β, human recombinant is available at Gentaur for Next week delivery.

A phosphorylating and an inactivating agent of glycogen synthase

Biomolecule/Target:

Alternates names: GSK, Glycogen synthase kinase-3 (GSK-3)

Synonyms: GSK, Glycogen synthase kinase-3 (GSK-3)

Background Information: Glycogen synthase kinase-3 (GSK-3) is a serine/theronine kinase that was first characterized by its role in intermediary metabolism. In mammals, serine kinase is encoded by two related genes called GSK-3α (51 kDa) and GSK-3β (46 kDa). GSK-3 has been implicated in the regulation of the c-Jun/AP-1 transcription factor and other intracellular signaling pathways.

Reconstitution Instructions: Reconstitute to 1 mg/ml in PBS containing 15% glycerol. The solution should be stored at –70°C, stable for up to 3 months.

NCBI Gene Symbol: GSK3B

Gene ID: 2932

NCBI Accession: P49841

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Additional Information

Size:
1 mg
Country of Manufacturing Origin:
USA
Country of Animal Origin:
USA
Gene Source:
Human
Recombinant:
Yes
Source:
E. coli.
Purity by SDS-PAGE:
≥90%
Assay:
SDS-PAGE
Purity:
N/A
Assay 2:
HPLC
Endotoxin Level:
N/A
Activity (Specifications/test method):
Activity of GSK-3β was determined by an in vitro kinase assay using 100 ng Tau as substrate and 1 µg of the recombinant GSK-3β in a 20 µl reaction containing 25 mM Tris-HCl, pH 7.5, 5 mM β-glycerol phosphate, 12 mM MgCl₂, 2 mM DTT, 0.1 M Na3VO4, and
Results:
N/A
Molecular Weight:
53.0-56.0 kDa
Storage Temperature:
-70°C
Shelf Life:
12 months
Concentration:
N/A
Appearance:
Lyophilized powder
Handling:
Centrifuge the vial prior to opening.
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