GHBP, human recombinant

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SKU:
4972-50
€185
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Description

GHBP, human recombinant is available at Gentaur for Next week delivery.

A carrier protein for growth hormone

Biomolecule/Target:

Alternates names: GHR, GHBP, GH receptor, Somatotropin receptor, Serum-binding protein

Synonyms: GHR, GHBP, GH receptor, Somatotropin receptor

Background Information: GHBP is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and interCellular signal transduction pathway leading to growth. A common alternate allele of this gene, called GHRd3, lacks exon three and has been well-characterized. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. Human Recombinant GHBP expressed from E. coli is a single, non-glycosylated, polypeptide chain containing 237 amino acids and having a molecular mass of 28.1 kDa. GHBP is purified by proprietary chromatographic techniques.

Reconstitution Instructions: Reconstitute in sterile dH₂O not less than 100 μg/ml. This solution can then be diluted into other aqueous buffers

NCBI Gene Symbol: GHR

Gene ID: 2690

NCBI Accession: P10912

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Additional Information

Size:
50 μg
Country of Manufacturing Origin:
USA
Country of Animal Origin:
USA
Gene Source:
Human
Recombinant:
Yes
Source:
E. coli
Purity by SDS-PAGE:
≥95%
Assay:
SDS-PAGE
Purity:
≥95%
Assay 2:
HPLC
Endotoxin Level:
<0.1 ng/μg
Activity (Specifications/test method):
N/A
Biological activity:
GHBP is fully biologically active as evidenced by its ability of forming 2:1 complex with HGH.
Results:
N/A
Molecular Weight:
30.3 kDa (19-256 aa + N-terminal poly-his tag)
Storage Temperature:
-20°C
Shelf Life:
12 months
Concentration:
N/A
Appearance:
Lyophilized protein
Handling:
Centrifuge the vial prior to opening.
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