Description
FRK, Active is available at Gentaur for Next week delivery.
Functions during G1 and S phase of the cell cycle and suppresses growth
Biomolecule/Target:
Alternates names: FRK, fyn-related kinase, FYN-related kinase, Nuclear tyrosine protein kinase RAK, Protein-tyrosine kinase 5
Synonyms: FRK, fyn-related kinase
Background Information: FRK (fyn-related kinase) or Rak is a nuclear tyrosine kinase and member of the Src sub-family. Restricted expression of FRK is detected in a broad range of cell lines with highest levels in epithelial cells. Increased expression of FRK has been shown in breast and renal cell carcinoma cell lines. In addition the retinoblastoma tumor susceptibility gene product pRb associates with FRK in vitro and in vivo (1). Overexpression of FRK in β-cells from the pancreas increases the susceptibility of these cells to β-cell-toxic events (hallmark of Type I diabetes)(2).
Reconstitution Instructions: N/A
NCBI Gene Symbol: FRK
Gene ID: 2444
NCBI Accession: NM_002031
Additional Information
Size: |
5 μg |
Country of Manufacturing Origin: |
USA |
Country of Animal Origin: |
USA |
Recombinant: |
Yes |
Source: |
Baculovirus (Sf9 insect cells) |
Purity by SDS-PAGE: |
≥90% |
Assay: |
SDS-PAGE |
Purity: |
N/A |
Assay 2: |
HPLC |
Endotoxin Level: |
N/A |
Activity (Specifications/test method): |
The specific activity of FRK was determined to be 997 nmol /min/mg as per activity assay protocol. |
Biological activity: |
N/A |
Results: |
N/A |
Molecular Weight: |
60.0 kDa |
Storage Temperature: |
-80°C |
Shelf Life: |
12 months |
Concentration: |
0.1mg/ml |
Appearance: |
Liquid |
Handling: |
Centrifuge the vial prior to opening. |