FRK, Active

FRK, Active is available at Gentaur for Next week delivery.

Functions during G1 and S phase of the cell cycle and suppresses growth

Biomolecule/Target:

Alternates names: FRK, fyn-related kinase, FYN-related kinase, Nuclear tyrosine protein kinase RAK, Protein-tyrosine kinase 5

Synonyms: FRK, fyn-related kinase

Background Information: FRK (fyn-related kinase) or Rak is a nuclear tyrosine kinase and member of the Src sub-family. Restricted expression of FRK is detected in a broad range of cell lines with highest levels in epithelial cells. Increased expression of FRK has been shown in breast and renal cell carcinoma cell lines. In addition the retinoblastoma tumor susceptibility gene product pRb associates with FRK in vitro and in vivo (1). Overexpression of FRK in β-cells from the pancreas increases the susceptibility of these cells to β-cell-toxic events (hallmark of Type I diabetes)(2).

Reconstitution Instructions: N/A

NCBI Gene Symbol: FRK

Gene ID: 2444

NCBI Accession: NM_002031