Description
FNDC4, human/mouse recombinant is available at Gentaur for Next week delivery.
An ortholog of FNDC5 with 50% identity and 86% similarity compared to Irisin.
Biomolecule/Target: FNDC4
Alternates names: Fibronectin Type III Domain-containing Protein 4; Fibronectin Type III Repeat-containing Protein 1
Synonyms: Fibronectin Type III Domain-containing Protein 4; Fibronectin Type III Repeat-containing Protein 1
Background Information: Irisin is a recently described exercise-induced hormone secreted by skeletal muscle in mice and humans. Irisin activates beige fat cells (beige cells have a gene expression pattern distinct from either white or brown fat and are preferentially sensitive to the polypeptide hormone Irisin). Irisin is cleaved from the type I membrane protein FNDC5 and improves systemic metabolism by increasing energy expenditure. FNDC4 is an ortholog of FNDC5 with 50% identity and 86% similarity compared to Irisin. FNDC4 as well as FNDC5 are extremely well conserved between species. The function of FNDC4 is unknown. The human FNDC4 gene is highly enriched in liver, brain tissue and adipocytes.
Reconstitution Instructions: Reconstitute with 100 μl sterile distilled water.
NCBI Gene Symbol: FNDC4
Gene ID: 64838
NCBI Accession: Q9H6D8
Additional Information
Size: |
10 μg |
Country of Manufacturing Origin: |
USA |
Country of Animal Origin: |
USA |
Gene Source: |
Human/Mouse |
Recombinant: |
Yes |
Source: |
E. coli |
Purity by SDS-PAGE: |
≥95% |
Assay: |
SDS-PAGE |
Purity: |
N/A |
Assay 2: |
N/A |
Endotoxin Level: |
<0.1 EU/μg by LAL method |
Activity (Specifications/test method): |
N/A |
Biological activity: |
N/A |
Results: |
N/A |
Molecular Weight: |
~16.0 kDa. (Extracellular domain, human (aa 45-167) / mouse (aa 41-163)) is untagged. FNDC4 extracellular domain has 100% identity between human, mouse, rat, dog and monkey. |
Storage Temperature: |
-20°C |
Shelf Life: |
6 months |
Concentration: |
N/A |
Appearance: |
Lyophilized |
Handling: |
Centrifuge the vial prior to opening. |