Factor Va, Human Plasma

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SKU:
4098-50
£135.37
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Description

Factor Va, Human Plasma is available at Gentaur for Next week delivery.

A serine protease co-ordinating multiple physiological functions

Biomolecule/Target: Factor Va

Alternates names: Activated protein C cofactor, Proaccelerin (labile factor)

Synonyms: Activated protein C cofactor, Proaccelerin (labile factor)

Background Information: Factor Va is a cofactor for the serine protease factor Xa, and in the presence of calcium ions they collectively assemble on a phospholipid surface to form the prothrombinase complex. The prothrombinase complex is responsible for the rapid conversion of prothrombin to thrombin. Factor Va is derived from the pro-cofactor, factor V, upon limited proteolysis by alpha-thrombin. The thrombin cleavage of factor V liberates two heavily glycosylated activation peptides from the central portion of the molecule which have no cofactor function. Factor Va is comprised of an NH2-terminal derived heavy chain (Mr=94,000) and a COOH-terminal derived light chain (Mr=74,000) which remain associated in the presence of calcium ions. The cofactor binds to phospholipid (cell membrane) surfaces and effectively serves as a receptor for membrane bound factor Xa. Complete assembly of the prothrombinase complex (factor Xa, factor Va, phospholipid, and calcium) results in a 300,000-fold increase in the rate of prothrombin conversion relative to the rate observed with factor Xa alone. The interaction between factor Va and factor Xa is mediated by both the heavy and light chain of factor Va, while the binding of prothrombin to factor Va is mediated solely by the heavy chain.

Reconstitution Instructions: N/A

NCBI Gene Symbol: F5

Gene ID: 2153

NCBI Accession: P12259

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Additional Information

Size:
50 μg
Country of Manufacturing Origin:
USA
Country of Animal Origin:
USA
Gene Source:
Human
Recombinant:
No
Source:
Human plasma
Purity by SDS-PAGE:
≥95%
Assay:
SDS-PAGE
Purity:
N/A
Assay 2:
HPLC
Endotoxin Level:
N/A
Activity (Specifications/test method):
Greater than 1000 u/mg (1u= Factor V activity in 1 ml normal human plasma)
Biological activity:
N/A
Results:
N/A
Molecular Weight:
94.0 kDa (heavy chain), 74.0 kDa (light chain)
Storage Temperature:
-20°C
Shelf Life:
12 months
Concentration:
N/A
Appearance:
Liquid
Handling:
Centrifuge the vial prior to opening.
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