DUSP10, human recombinant

DUSP10, human recombinant is available at Gentaur for Next week delivery.

Negatively regulates members of the MAPK superfamily

Biomolecule/Target: DUSP10

Alternates names: Dual specificity protein phosphatase 10, MKP5

Synonyms: Dual specificity protein phosphatase 10, MKP5

Background Information: DuSP10 (Dual specificity protein phosphatase 10) belongs to the protein-tyrosine phosphatase family. Dual specificity protein phosphatases (DuSPs) inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAPK superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. DuSP10 has been shown to interact with MAPK14 and MAPK8. When expressed in mammalian cells, DuSP10 blocks the enzymatic activation of MAP kinases with the selectivity p38 approximately JNK/SAPK >> ERK. Recombinant human DuSP10 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

Reconstitution Instructions: N/A

NCBI Gene Symbol: DUSP10

Gene ID: 11221

NCBI Accession: Q9Y6W6