Cyclin-dependent kinase inhibitor 2A, Human Recombinant

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SKU:
P1008-20
£135.37
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Description

Cyclin-dependent kinase inhibitor 2A, Human Recombinant is available at Gentaur for Next week delivery.

A negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6

Biomolecule/Target: Cyclin-dependent kinase inhibitor 2A

Alternates names: p16-INK4a, Cyclin-Dependent Kinase Inhibitor 2A, Cyclin-Dependent Kinase 4 Inhibitor A, CDK4I, p16INK4A, p16-INK4, Multiple Tumor Suppressor 1, MTS-1

Synonyms: p16-INK4a, Cyclin-Dependent Kinase Inhibitor 2A, Cyclin-Dependent Kinase 4 Inhibitor A, CDK4I, p16INK4A, p16-INK4, Multiple Tumor Suppressor 1, MTS-1

Background Information: Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein. This activity has the effect of suppressing tumor formation and growth, and of inducing replicative senescence in various normal cells, including stem cells. The expression of Cyclin-Dependent Kinase Inhibitor 2A steadily increases with age, and tends to accumulate in stem cell compartments. The deletion, rearrangement, or mutation of the Cyclin-Dependent Kinase Inhibitor 2A gene is frequently found in melanomas, as well as in certain other types of cancer.

Reconstitution Instructions: Reconstitute in sterile PBS (pH 8.0) to a concentration of 0.1-1.0 mg/ml. Do not vortex. Additional carrier protein (example 0.1% BSA) is recommended for long term storage.

NCBI Gene Symbol: CDKN2A

Gene ID: 1029

NCBI Accession: P42771

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Additional Information

Size:
20 μg
Country of Manufacturing Origin:
USA
Country of Animal Origin:
USA
Gene Source:
Human
Recombinant:
Yes
Source:
E. coli
Purity by SDS-PAGE:
≥95%
Assay:
SDS-PAGE
Purity:
≥95%
Assay 2:
HPLC
Endotoxin Level:
< 1 EU/μg
Activity (Specifications/test method):
N/A
Biological activity:
N/A
Results:
N/A
Molecular Weight:
16.5 kDa
Storage Temperature:
-20°C
Shelf Life:
12 months
Concentration:
N/A
Appearance:
Dry powder
Handling:
Centrifuge the vial prior to opening.
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