CNTF, rat recombinant

CNTF, rat recombinant is available at Gentaur for Next week delivery.

A potent neural factor promoting survivability and differentiation of neuronal cell types.

Biomolecule/Target: CNTF

Alternates names: HCNTF, CNTF, Ciliary Neurotrophic Factor.

Synonyms: HCNTF, CNTF, Ciliary Neurotrophic Factor.

Background Information: CNTF is a polypeptide hormone whose actions appear to be restricted to the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. The protein is a potent survival factor for neurons and oligodendrocytes and may be relevant in reducing tissue destruction during inflammatory attacks. A mutation in this gene, which results in aberrant splicing, leads to ciliary neurotrophic factor deficiency, but this phenotype is not causally related to neurologic disease. CNTF is a survival factor for various neuronal cell types and seems to prevent the degeneration of motor axons after axotomy. CNTF Recombinant Rat produced in E.Coli is a single, non-glycosylated polypeptide chain containing 200 amino acids and having a molecular mass of 22834 Dalton. The CNTF is purified by proprietary chromatographic techniques.

Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in sterile ddH₂O or 0.4 % NaHCO₃ adjusted to pH 8-9 to a concentration ≥ 100 µg/ml. This solution can then be diluted into other aqueous buffer, preferably in the presence of carrier protein.

NCBI Gene Symbol: CNTF

Gene ID: 1270

NCBI Accession: P26441