CDNF, Human Recombinant

CDNF, Human Recombinant is available at Gentaur for Next week delivery.

Promotes survival, growth and function of dopamine specific neurons

Biomolecule/Target: CDNF

Alternates names: Cerebral dopamine neurotrophic factor, ARMETL1

Synonyms: Cerebral dopamine neurotrophic factor, ARMETL1

Background Information: CDNF is a secreted neurotrophic factor that is expressed in brain, neuronal and certain non-neuronal tissues. It has been shown to promote survival, growth and function of dopamine specific neurons. CDNF and its structural homolog MANF, each contain an N-terminal saposin-like lipid binding domain, and a carboxyl-terminal domain, which is not homologous to previously characterized protein structures. CDNF and MANF can prevent 6-OHDA induced degeneration of dopaminergic neurons by triggering survival pathways in a rat experimental model of Parkinson disease. Recombinant human CDNF is an 18.5 kDa protein consisting of 162 amino acids including 8 cysteine residues.

Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.

NCBI Gene Symbol: CDNF

Gene ID: 441549

NCBI Accession: Q49AH0