BRD4 bromodomains 1 and 2 (49-460 aa) (GST-tagged), Human recombinant

(No reviews yet) Write a Review
SKU:
7651-20
£135.37
Frequently bought together:

Description

BRD4 bromodomains 1 and 2 (49-460 aa) (GST-tagged), Human recombinant is available at Gentaur for Next week delivery.

A protein involved in chromatin targeting

Biomolecule/Target: BRD4

Alternates names: Bromodomain containing 4; HUNK1; MCAP

Synonyms: BRD4 bromodomains 1 and 2 (49-460 aa) (GST-tagged), Human recombinant

Background Information: The acetylation of histone lysine residues plays a crucial role in the epigenetic regulation of gene transcription. A bromodomain is a protein domain that recognizes acetylated lysine residues such as those on the N-terminal tails of histones. This recognition is often a prerequisite for protein-histone association and chromatin remodeling. These domains function in the linking of protein complexes to acetylated nucleosomes, thereby controlling chromatin structure and gene expression. Thus, bromodomains serve as “readers” of histone acetylation marks regulating the transcription of target promoters. The BET family of proteins, defined by tandem Bromodomains and an Extra Terminal domain, include BRD2, BRD3, BRD4, and BRDT. The BET proteins play a key role in many cellular processes, including inflammatory gene expression, mitosis, and viral/host interactions. The isolated individual or tandem bromodomains of BRD2 and BRD4 have been shown to bind acetylated histone tails, serving to couple histone acetylation marks to the transcriptional regulation of target promoters. Small molecule inhibitors of these interactions hold promise as useful therapeutics for human disease.

Reconstitution Instructions: N/A

NCBI Gene Symbol: BRD4

Gene ID: 23476

NCBI Accession: O60885

View AllClose

Additional Information

Size:
20 μg
Country of Manufacturing Origin:
USA
Country of Animal Origin:
USA
Gene Source:
Human
Recombinant:
Yes
Source:
E. coli
Purity by SDS-PAGE:
≥90%
Assay:
SDS-PAGE
Purity:
N/A
Assay 2:
HPLC
Endotoxin Level:
N/A
Activity (Specifications/test method):
N/A
Biological activity:
N/A
Results:
N/A
Molecular Weight:
73.4 kDa (49-460 aa + GST Tag)
Storage Temperature:
-80°C
Shelf Life:
6 months
Concentration:
N/A
Appearance:
Liquid
Handling:
Centrifuge the vial prior to opening.
View AllClose

0 Reviews

View AllClose