BLK, Active

BLK, Active is available at Gentaur for Next week delivery.

Stimulates insulin synthesis and secretion in response to glucose

Biomolecule/Target:

Alternates names: BLK, B lymphocyte kinase, p55-Blk

Synonyms: BLK, B lymphocyte kinase

Background Information: Blk, also known as B lymphoid kinase, is a 55 kd tyrosine kinases with a SH3, SH2 and catalytic domains that contain consensus sequences of the src protein tyrosine kinase family. Blk is expressed specifically in the B cell lineage and plays a role in signal transduction pathway that is restricted to B lymphoid cells (1). Stimulation of resting B-lymphocytes with antibodies to surface immunoglobulin (sIgD or sIgM) induces activation of Blk (2). Upon activation, the SH2 domain of Blk binds more than 10 distinct phosphoprotein including those of 72, 76, 115, and 130 kd (3). Blk prefers peptide substrates of the structure I/L-Y-D/E-X-L which resemble critical features of the ITAM motifs found in, e.g. the intracellular components Ig-α and Ig-β of the β cell receptor. Blk has a strong preference for a negatively charged amino acid in position +1 (4).

Reconstitution Instructions: N/A

NCBI Gene Symbol: BLK

Gene ID: 640

NCBI Accession: P51451