Alix, Human Recombinant

Alix, Human Recombinant is available at Gentaur for Next week delivery.

Cytoplasmic protein that interacts with apoptosis-associated proteins

Biomolecule/Target:

Alternates names: Programmed cell death 6 interacting protein, AIP1, PDCD6IP, DRIP4, HP95

Synonyms: Programmed cell death 6 interacting protein, AIP1, PDCD6IP, DRIP4, HP95

Background Information: Alix, also known as PDCD6IP, is a cytoplasmic protein that interacts with apoptosis-associated proteins (ALG-2 and PDCD6) and with the endocytosis-regulator CIN85. It's involved in concentration and sorting of cargo proteins of the multivesicular body for incorporation into intralumenal vesicles that are generated by invagination and scission from the limiting membrane of the endosome. Overexpression of this protein and endophilins results in cytoplasmic vacuolization which may be partly responsible for the protection against cell death. Recombinant PDCD6IP protein was expressed in E. coli and purified by using conventional chromatography techniques.

Reconstitution Instructions:

NCBI Gene Symbol: PDCD6IP

Gene ID: 10015

NCBI Accession: Q8WUM4