BioVision Proteins
Active SIRT6 (His-tagged), human recombinant
- SKU:
- 7699-20
Description
Active SIRT6 (His-tagged), human recombinant is available at Gentaur for Next week delivery.
His tagged Human SIRT6 from E.Coli, AOF, ≥90% pure, biologically active.
Biomolecule/Target: SIRT6
Alternates names: SIRT6, NAD-dependent Deacetylase Sirtuin-6; Mono-ADP-ribosyltransferase Sirtuin 6; SIR2-like Protein 6; SIR2L6
Synonyms: SIRT6, NAD-dependent Deacetylase Sirtuin-6; Mono-ADP-ribosyltransferase Sirtuin 6; SIR2-like Protein 6; SIR2L6
Background Information: Human Sirtuins function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. Sirtuin 6 (SIRT6) is a NAD-dependent protein deacetylase with activity towards Lys-9 and Lys-56 of histone H3. It modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. It is required for genomic stability and for normal IGF1 serum levels and normal glucose homeostasis. It also regulates cellular senescence and apoptosis. Unlike most sirtuins, SIRT6 preferentially removes long-chain fatty-acyl, rather than acetyl, protein modifications. This activity regulates secretion of the inflammation-associated protein TNF-α.
Reconstitution Instructions: N/A
NCBI Gene Symbol: SIRT6
Gene ID: 51548
NCBI Accession: Q8N6T7
Additional Information
Size: |
20 µg |
Country of Manufacturing Origin: |
USA |
Country of Animal Origin: |
USA |
Gene Source: |
Human |
Recombinant: |
Yes |
Source: |
E. coli. |
Purity by SDS-PAGE: |
≥90% |
Assay: |
SDS-PAGE |
Purity: |
N/A |
Assay 2: |
HPLC |
Endotoxin Level: |
N/A |
Activity (Specifications/test method): |
BioVision’s Active His-tagged SIRT6 has been tested for its activity using Sirtuin Activity Assay Kit (K324-100). It has a specific activity of >3 mU/mg (One unit of Sirtuin activity is the amount of enzyme that hydrolyzes the substrate to yield 1 µm |
Biological activity: |
>3 mU/mg |
Results: |
>3 mU/mg |
Molecular Weight: |
Human SIRT6 is a 41.3 kDa (1-355 aa + N-terminal polyhistidine tag) protein. It runs as ~30 kDa during SEC and ~47 kDa on a SDS-PAGE. |
Storage Temperature: |
-80°C |
Shelf Life: |
12 months |
Concentration: |
1 mg/ml |
Appearance: |
Liquid |
Handling: |
Centrifuge the vial prior to opening. |
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