Description
Active Porcine Calpain 1 is available at Gentaur for Next week delivery.
A cysteine protease involved in apoptosis activation
Biomolecule/Target: Calpain 1
Alternates names: Calpain-1 catalytic subunit, Calcium-activated neutral proteinase 1, CANP 1, Calpain mu-type, Calpain-1 large subunit, Micromolar-calpain
Synonyms: Calpain 1
Background Information: The activity of Calpain activity is attributed to two main isoforms: n-calpain and m-calpain, which are ubiquitously, expressed proteases implicated in cellular migration, cell cycle progression, degenerative processes and cell death. These heterodimeric enzymes are composed of distinct catalytic subunits, encoded by Capn1 (n-calpain) or Capn2 (m-calpain), and a common regulatory subunit encoded by Capn4. CAPN1 is a calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of the substrates involved in cytoskeletal remodeling and signal transduction. CAPN1 is activated by micromolar concentrations of calcium and inhibited by calpastatin.
Reconstitution Instructions: N/A
NCBI Gene Symbol: CAPN1
Gene ID: 397027
NCBI Accession: P35750
Additional Information
Size: |
100 μg |
Country of Manufacturing Origin: |
USA |
Country of Animal Origin: |
USA |
Gene Source: |
Porcine |
Recombinant: |
No |
Source: |
Porcine Erythrocytes |
Purity by SDS-PAGE: |
≥85% |
Assay: |
SDS-PAGE |
Purity: |
N/A |
Assay 2: |
HPLC |
Endotoxin Level: |
N/A |
Activity (Specifications/test method): |
N/A |
Biological activity: |
≥ 1000 units/mg protein prior to freezing. |
Results: |
≥ 1000 units/mg |
Molecular Weight: |
110 kDa |
Storage Temperature: |
-70°C |
Shelf Life: |
12 months |
Concentration: |
N/A |
Appearance: |
Liquid |
Handling: |
Centrifuge the vial prior to opening. |