Active Porcine Calpain 1

Active Porcine Calpain 1 is available at Gentaur for Next week delivery.

A cysteine protease involved in apoptosis activation

Biomolecule/Target: Calpain 1

Alternates names: Calpain-1 catalytic subunit, Calcium-activated neutral proteinase 1, CANP 1, Calpain mu-type, Calpain-1 large subunit, Micromolar-calpain

Synonyms: Calpain 1

Background Information: The activity of Calpain activity is attributed to two main isoforms: n-calpain and m-calpain, which are ubiquitously, expressed proteases implicated in cellular migration, cell cycle progression, degenerative processes and cell death. These heterodimeric enzymes are composed of distinct catalytic subunits, encoded by Capn1 (n-calpain) or Capn2 (m-calpain), and a common regulatory subunit encoded by Capn4. CAPN1 is a calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of the substrates involved in cytoskeletal remodeling and signal transduction. CAPN1 is activated by micromolar concentrations of calcium and inhibited by calpastatin.

Reconstitution Instructions: N/A

NCBI Gene Symbol: CAPN1

Gene ID: 397027

NCBI Accession: P35750