Active Human Caspases Group I, Active Human

Active Human Caspases Group I, Active Human is available at Gentaur for Next week delivery.

Set of recombinant proteases involved in apoptosis

Biomolecule/Target:

Alternates names: N/A

Synonyms: Active Human Caspases Group I, Active Human

Background Information: The caspase family consists of more than 10 members. Based on their extended substrate specificities, these enzymes were divided into three major groups: Group I (contains caspase-1,-4,-5), Group II (contains caspase-2,-3,-7), and Group III (contains caspase-6,-8,-9,-10). Evidences have suggested that Group I caspases are involved primarily in the production of inflammatory cytokines, while group II and III enzymes function in apoptosis as effectors and upstream activators, respectively. The group I caspases were expressed in E. coli and routinely tested for their ability to enzymatically cleave the substrate YVAD-pNA (for caspase-1) and WEHD-pNA (for caspase-4 & -5).

Reconstitution Instructions: Reconstitute to 1 unit/µl in PBS containing 15% glycerol.

NCBI Gene Symbol: CASP1 CASP4 CASP5

Gene ID: CASP1- 834 CASP4- 837 CASP5 -838

NCBI Accession: CASP1- NP_150634.1 CASP4- P49662 CASP5- P51878