Description
ACK1, Human Recombinant is available at Gentaur for Next week delivery.
Non-receptor tyrosine-protein kinase that is implicated in cell migration, survival, growth and proliferation
Biomolecule/Target:
Alternates names: Tyrosine kinase non-receptor protein 2, CDC42 kinase 1, TNK2
Synonyms: Tyrosine kinase non-receptor protein 2, CDC42 kinase 1, TNK2
Background Information: Activated CDC42 kinase 1, also known as ACK1, is an enzyme that is encoded by the TNK2 gene in humans. TNK2 gene encodes a non-receptor tyrosine kinase, ACK1, that binds to multiple receptor tyrosine kinases e.g. EGFR, MERTK, AXL, HER2 and insulin receptor (IR). ACK1 also interacts with Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain.
Reconstitution Instructions:
NCBI Gene Symbol: TNK2
Gene ID: 10188
NCBI Accession: Q07912
Additional Information
Size: |
50 μg |
Adwords: |
False |
Country of Manufacturing Origin: |
USA |
Country of Animal Origin: |
USA |
Gene Source: |
Human |
Recombinant: |
True |
Source: |
Insect Cells (sf9) |
Purity by SDS-PAGE: |
>95% |
Assay: |
SDS-PAGE |
Activity (Specifications/test method): |
The specific activity is ≥ 500 U/mg. Specific activity was tested using Biovision ADPsensor™ Universal Kinase Activity Assay Kit (Cat# K212). |
Molecular Weight: |
43.5 KDa (aa 110-476, N-His tag) |
Storage Temperature: |
-70°C |
Shelf Life: |
12 months |
Appearance: |
Liquid |
Handling: |
Centrifuge the vial prior to opening. |