ACK1, Human Recombinant

ACK1, Human Recombinant is available at Gentaur for Next week delivery.

Non-receptor tyrosine-protein kinase that is implicated in cell migration, survival, growth and proliferation

Biomolecule/Target:

Alternates names: Tyrosine kinase non-receptor protein 2, CDC42 kinase 1, TNK2

Synonyms: Tyrosine kinase non-receptor protein 2, CDC42 kinase 1, TNK2

Background Information: Activated CDC42 kinase 1, also known as ACK1, is an enzyme that is encoded by the TNK2 gene in humans. TNK2 gene encodes a non-receptor tyrosine kinase, ACK1, that binds to multiple receptor tyrosine kinases e.g. EGFR, MERTK, AXL, HER2 and insulin receptor (IR). ACK1 also interacts with Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain.

Reconstitution Instructions:

NCBI Gene Symbol: TNK2

Gene ID: 10188

NCBI Accession: Q07912