MMP-3 Activity Fluorometric Assay Kit

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SKU:
K783-100
$421
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Description

MMP-3 Activity Fluorometric Assay Kitis available at Gentaur for Next week Delivery.

Highly Sensitive Assay, HTS.

Description:

The matrix metalloproteinase-3 (MMP-3, stromelysin-1) exhibits a number of activities that would make it a particularly good tumor promoter. Like several other MMPs, MMP-3 was first cloned and later recloned as a cancer-specific gene. In addition to degrading numerous extracellular matrix components, MMP-3 can activate gelatinase B, the collagenases and several serpin-type serine proteinase inhibitors. Moreover, it can release a number of cell surface molecules, including E-cadherin, a known contributor to cancer development. In BioVision’s MMP-3 Assay Kit, MMP-3 hydrolyzes a specific FRET substrate to release the quenched fluorescent group Mca, which can be detected fluorometrically at Ex/Em = 325/393 nm. The kit provides a rapid, simple, sensitive and reliable test which can also be used as a high throughput assay of MMP-3 activity. The assay sensitivity is < 50 µU. This kit can be used with our MMP-3 inhibitor, GM6001 (Biovision #1799) as a control. In addition, we also offer a human recombinant MMP-3 enzyme (Biovision #7783) and a MMP-3 inhibitor Screening Kit (Biovision #K793-100), separately.

Applications:

Sample Typ:e Cell and tissue culture supernatants, urine, plasma and serum, as well as many other biological fluids, growth medium, food, etc.

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Features and Benefits:

• Simple procedure; takes ~ 60 minutes • Fast and convenient • Sensitive assays for measuring MMP-3 in various biological samples

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Additional Information

Size:
100 assays
Storage Conditions:
4°C-20°C
Shipping Conditions:
gel pack
Shelf life:
12 months
Category:
MMP3
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