BioSim™ anti-Rituximab (Mabthera®) (Human) ELISA Kit

BioSim™ anti-Rituximab (Mabthera®) (Human) ELISA Kitis available at Gentaur for Next week Delivery.

A Sandwich ELISA kit for the quantitative measurement of antibody against Rituximab in human serum or plasma..

Description:

Rituximab (Mabthera®) is a genetically engineered chimeric murine/human monoclonal antibody specific to CD20. CD20 is an approximately 35 KDa transmembrane phosphoprotein involved in the activation, proliferation, and differentiation of B-lymphocytes. It is absent in terminally differentiated plasma cells. The Fab domain of rituximab binds to the CD20 antigen on B-lymphocytes and the Fc domain recruits immune effector functions to induce apoptosis in B cells. It is used in treating leukemias and lymphomas, some autoimmune disorders, and organ transplant. However, some patients develop unwanted immunogenicity, which leads to production of anti-drug-antibodies (ADAs) inactivating the therapeutic effects of the treatment and, in rare cases, inducing adverse effects. BioVision’s BioSimTM anti-Rituximab ELISA kit is designed to quantify/measure the antibody against Rituximab with high specificity and sensitivity in biological matrices.

Applications: This ELISA kit is used for quantitative measurement of antibody against Rituximab in human serum and plasma

Sample Typ:e Human serum and plasma

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Features and Benefits:

Easy, convenient, sensitive and time-saving method to measure the level of antibody against Rituximab in human serum and plasma. Detection Range: 62 - 500 ng/ml Sensitivity: 30 ng/ml Assay Precision: Intra-Assay: CV < 15%; Inter-Assay: CV < 15% (CV (%) = SD/mean X 100) Cross Reactivity: Rituximab (Rituxan®, Mabthera®) infusion camouflages/masks the presence of antibody to rituximab (ATR) in serum/plasma samples. Therefore, blood sampling time is critical for detection of ATR. It is convenient to obtain blood sample just before the infusion or at least 2 weeks after the infusion of Rituximab (Rituxan®, Mabthera®) Recovery rate: 85 – 115% with normal human serum samples with known concentrations