BioSim™ anti-Filgrastim (Human) ELISA Kit

BioSim™ anti-Filgrastim (Human) ELISA Kitis available at Gentaur for Next week Delivery.

An ELISA kit for the quantitative measurement of antibody against Filgrastim in human serum or plasma..

Description:

Filgrastim is a recombinant, non-pegylated human granulocyte colony-stimulating factor (G-CSF) analog. It binds to the G-CSF receptor and stimulates the production of neutrophils in the bone marrow. As a G-CSF analog, it controls the proliferation of committed progenitor cells and influences their maturation into mature neutrophils. Filgrastim is used in patients with acute myeloid leukemia receiving induction or consolidation chemotherapy. It is also used in cancer patients receiving bone marrow transplants. However, some patients develop unwanted immunogenicity, which leads to the production of anti-drug antibodies (ADAs) inactivating the therapeutic effects of the treatment and, in rare cases, inducing adverse effects. BioVision’s BioSimTM anti-Filgrastim (Human) ELISA kit is designed to detect antibodies against Filgrastim with high specificity and sensitivity in biological matrices. The kit is based on the sandwich principle. Controls and samples are incubated in the microtiter plate coated with the drug Filgrastim. After incubation, the wells are washed, and the enzymatic activity is detected by the addition of chromogen-substrate. The enzyme-substrate reaction is terminated with an acidic stop solution. The color developed is proportional to the amount of antibodies specific for Filgrastim present in the samples and standards. The quantitative test results can be determined using the standard curve.

Applications: This ELISA kit is used for quantitative measurement of antibody against Filgrastim in human serum and plasma

Sample Typ:e Human serum and plasma

Alternate Name: GCSF, CSF3OS, C17orf33, CSF3

Features and Benefits:

Cross Reactivity: Filgrastim infusion camouflages/masks the presence of antibody to Filgrastim (ATT) in serum/plasma samples. Therefore, blood sampling time is critical for detection of ATT. It is convenient to obtain blood sample just before the infusion of Filgrastim or at least 2 weeks after the infusion of Filgrastim. Detection Range: 3.1 - 50 ng/ml Sensitivity: 3.1 ng/ml Easy, convenient, sensitive and time-saving method to measure the level of antibody against Filgrastim in human serum and plasma.