dna motoring

DNA structure and increase angular deviations

First of all, the data presented in the work demonstrate the dependence of the frequency and amplitude of oscillations of a DNA molecule both on the specific nucleotide sequence (for example, homologous areas of each type of nitrogenous bases, Figure 5) and on different lengths of homologous sequences (Figure 6). At the same time, Figure 5 shows that the value of the average angular deviations of the first chain increases in the DNA molecule, which has a substitution of nitrogenous bases in the middle (from the 470th to the 510th nucleotide) for areas with the length of 40 nucleotides in the following row: 40C > 40G > 40T > 40A. In addition, they all exceed the mean angular deviations of the initial DNA molecule, which has a heterogeneous sequence of nitrogenous bases.

In general, these data indicate both a lower (by 24% or more) sensitivity of heterogeneous DNA sequences to external periodic force effects, and a greater vulnerability of areas with nitrogenous bases of three hydrogen bonds (cytosine and guanine) in comparison with the sequences formed from adenine and thymine, the average angular deviations of which were 1.2–1.9 times lower than that of the molecules with the replacement of 40 consecutive.