TLR1 Antibody

TLR1 Antibodyis available at Gentaur for Next week Delivery.

Description: The TLR (toll-like receptors) family of proteins are characterized by a highly conserved Toll homology (TH) domain, which is essential for Toll-induced signal transduction. TLR1, as well as the other TLR family members, are type I transmembrane receptors that characteristically contain an extracellular domain consisting of several leucine-rich regions along with a single cytoplasmic Toll/IL-1R-like domain. TLR2 and TLR4 are activated in response to lipopolysacchride (LPS) stimulation, which results in the activation and translocation of NFκB and sμggests that these receptors are involved in mediating inflammatory responses. Expression of TLR receptors is highest in peripheral blood leukocytes, macrophages, and monocytes. TLR6 is highly homologous to TLR1, sharing greater that 65% sequence identity, and, like other members of TLR family, it induces NFκB signaling upon activation.

Immunogen Sequence:Recombinant human TLR1

Target Alternative Name:Toll-like Receptor 1

Species Reactivities:Human

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Formulation:100 µl antigen affinity purified goat polyclonal antibody in phosphate-buffered saline (PBS) containing 50% glycerol, 1% BSA, and 0.02% thimerosal.

Purification: Affinity purified

Application:Western blot, ELISA

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Application And Usages:Western blotting (1:200-1000) and ELISA (1:100-500). However, the optimal concentrations should be determined individually.

Handling:The antibody solution should be gently mixed before use.